Adolescents (10 to 17 years of age) with HeFH: starting dose is 10 mg/day maximum recommended dose is 40 mg/day.

Due to the increased risk of myopathy, including rhabdomyolysis, associated with the 80 mg dose of simvastatin tablets, patients unable to achieve their LDL-C goal utilizing the 40 mg dose of simvastatin tablets should not be titrated to the 80 mg dose, but should be placed on alternative LDL-C-lowering treatment(s) that provides greater LDL-C lowering.Patients who are currently tolerating the 80 mg dose of simvastatin tablets who need to be initiated on an interacting drug that is contraindicated or is associated with a dose cap for simvastatin should be switched to an alternative statin with less potential for the drug-drug interaction.Due to the increased risk of myopathy, including rhabdomyolysis, use of the 80 mg dose of simvastatin tablets should be restricted to patients who have been taking simvastatin 80 mg chronically (e.g., for 12 months or more) without evidence of muscle toxicity.Recommended starting dose for patients at high risk of CHD is 40 mg/day.Recommended usual starting dose is 10 or 20 mg once a day in the evening.Simvastatin tablets have not been studied in Fredrickson Types I and V dyslipidemias. Reduce elevated total-C, LDL-C, and Apo B in boys and postmenarchal girls, 10 to 17 years of age with heterozygous familial hypercholesterolemia after failing an adequate trial of diet therapy.Reduce total-C and LDL-C in adult patients with homozygous familial hypercholesterolemia.Reduce elevated TG in patients with hypertriglyceridemia and reduce TG and VLDL-C in patients with primary dysbetalipoproteinemia.Reduce elevated total-C, LDL-C, Apo B, TG and increase HDL-C in patients with primary hyperlipidemia (heterozygous familial and nonfamilial) and mixed dyslipidemia.Reduce the risk of total mortality by reducing CHD deaths and reduce the risk of non-fatal myocardial infarction, stroke, and the need for revascularization procedures in patients at high risk of coronary events.If you have any feature requests, suggestions or you simply need help, please visit and our responsive support team will prioritize your request.Simvastatin tablets are an HMG-CoA reductase inhibitor (statin) indicated as an adjunctive therapy to diet to: is a multiple Webby Award nominee and attracts more than 24 million U.S. Providing free, peer-reviewed, accurate and independent data on more than 24,000 prescription drugs, over-the-counter medicines & natural products. Always consult with a physician.įollow us on Twitter for tips and updates.ĭ is the most popular, comprehensive and up-to-date source of drug information online. The full edition is specifically designed for healthcare professionals and people on the move or with limited internet access.ĭ does not provide medical or treatment advice. See Also: Purchase the Pro edition to install more than 10,000 images directly on your mobile device and get additional information such as NDC Codes, coating, clarity and repackagers. Connects to for additional information (where available). Access a wealth of information, including drug images, description/indication, pregnancy category, CSA schedule, strength and Rx/OTC availability. Search by imprint, drug name, shape and color. The Pill Identifier app is a searchable database which includes more than 24,000 Rx/OTC medications found in the U.S.

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